The original Croatian pharmacopoeia from 1901

The second edition of the Croato-Slavonian Pharmacopoeia was published in Zagreb in 1901. As the original scientific work of two university professors, Gustav Janečcek and Julije Domac, the Pharmacopoeia had strong scientific foundations and introduced a number of innovations. For the first time, a pharmacopoeia prescribed optical rotation for the examination of essential oils, introduced the quantitative analysis of active ingredients in galenic preparations, standardized the boiling points at the atmospheric pressure of 760 mm Hg, and was the only one to prescribe antidotes for herbal drugs and preparations which may cause poisoning. It received extremely positive reviews from the most prominent European pharmaceutical experts. It was written in two languages, Latin and Croatian, and had a wider significance, since it reflected the aspirations of the Croatian people for independence.