@article {Hryhorczuk:2022:1076-2752:331,
title = "t(14;18) Translocations in Dioxin-Exposed Workers",
journal = "Journal of Occupational and Environmental Medicine",
parent_itemid = "infobike://wk/jom",
publishercode ="wk",
year = "2022",
volume = "64",
number = "4",
publication date ="2022-04-16T00:00:00",
pages = "331-339",
itemtype = "ARTICLE",
issn = "1076-2752",
eissn = "1536-5948",
url = "https://www.ingentaconnect.com/content/wk/jom/2022/00000064/00000004/art00023",
doi = "doi:10.1097/JOM.0000000000002427",
keyword = "dioxin, t(14 ;18) translocations, chloracne",
author = "Hryhorczuk, Daniel and Dardynskaia, Irina and Hirt, Carsten and Dardynskiy, Oleg and Turner, Wayman and Ruestow, Peter and Bartell, Scott and Steenland, Kyle and Zvinchuk, Oleksandr and Baccarelli, Andrea A.",
abstract = "
Objective:
To determine if occupational exposure to dioxins is associated with an increased frequency of t(14;18) translocations.Methods:
A cross-sectional analysis of serum dioxin levels and t(14;18) frequencies in peripheral
blood mononuclear cells in 218 former chemical plant workers and 150 population controls.Results:
The workers had significantly higher geometric mean serum levels of 2,3,7,8-TCDD (26.2 vs 2.5 ppt) and TEQ (73.8 vs 17.7 ppt) than controls.
There were no significant differences in the prevalence or frequency of t(14;18) translocations in the workers compared to controls. Among former workers with current or past chloracne who were t(14;18) positive, the frequency of translocations significantly increased with quartiles of 2,3,7,8-TCDD
and TEQ.Conclusion:
Chloracne appears to modulate the association between dioxin exposure and increased frequency of t(14;18) translocations.",
}