Effect of different phenolic compounds on α-amylase activity: screening by microplate-reader based kinetic assay
The inhibitory effect of different polyphenolic plant compounds on α-amylase activity was investigated in vitro. A kinetic assay was performed using 96-well-plates. Acarbose was used as positive control (IC50: 23.2 μM). Some of the tested compounds, occurring
in plants traditionally used in anti-diabetic tea species, showed an inhibition of the enzyme in physiological concentrations, e.g. luteolin, tannic acid, and isochlorogenic acid.
Document Type: Short Communication
Affiliations: 1: Institut für Pharmazie, Freie Universität, Berlin, Germany 2: Institut für Pharmazie, Freie Universität, Königin-Luise-Str. 2+4, Berlin, D-14195, Germany, Email: [email protected]
Publication date: 01 October 2005
- Pharmazie is a leading journal in the field of pharmaceutical sciences. As a peer-reviewed scientific journal, Pharmazie is regularly indexed in the relevant databases like Web of science, Journal Citation Reports and many others. The journal is open for submissions from the whole spectrum of pharnaceutical sciences including Pharmaceutical Chemistry, Experimental and Clinical Pharmacology, Drug Analysis, Pharmaceutics, Pharmaceutical Biology, Clinical Pharmacy etc.
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